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Mechanism of chronic insomnia

Exploring the mechanism of chronic insomnia

This video explores the science behind chronic insomnia, including difficulties with sleep initiation and maintenance, daytime impairments, and neurological factors.5 Understand the role of orexin neurons in wakefulness and discover how their persistent activity is thought to lead to overactive wake signalling at night, preventing sleep.6-9

Promotional material from Idorsia Pharmaceuticals UK Ltd.

References

1 – QUVIVIQ™▼ (daridorexant) Idorsia Pharmaceuticals Ltd, Summary of Product Characteristics. 

2 – Roch C, et al. Psychopharmacology. 2021; 238(10): 2693–2708.

3 – NICE Clinical Knowledge Summary (CKS) Insomnia: Scenario: Managing long-term insomnia (more than 3 months duration). Available at: https://cks.nice.org.uk/topics/insomnia/management/managing-insomnia/. Updated May 2025. Accessed June 2025.

4 – Mignot E, et al. Lancet Neurol. 2022; 21(2): 125–139.

5 – American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision. Arlington, VA, American Psychiatric Association Publishing, 2022.

6 – Scammell TE and Winrow CJ. Annu Rev Pharmacol Toxicol. 2011; 51: 243–266.

7 – Riemann D, et al. Sleep Med Rev. 2010; 14(1): 19–31.

8 – Nofzinger E, et al. Am J Psychiatry. 2004; 161: 2126–2129.

9 – Saper C, et al. Nature. 2005; 437(7063): 1257–1263.

This information is intended for UK healthcare professionals.

Adverse events must be reported. Healthcare professionals are asked to report any suspected adverse reactions via http://www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in Google play or Apple App store. Adverse events should also be reported to ds.safety.uk@idorsia.com.

UK-DA-00790
| Date of preparation: July 2025
Copyright © 2026 Idorsia Pharmaceuticals Ltd

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Discover how QUVIVIQ™ ▼ (daridorexant) is different to other hypnotics1,2:

Works differently1,2

Is taken differently1,3

Is experienced differently1,4

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References

1 – QUVIVIQ™ Idorsia Pharmaceuticals LTD, summary of product characteristics. Last updated: September 2024. 2 – Roch C, et al. Psychopharmacology. 2021; 238(10): 2693–2708. 3 – Mignot E, et al. Lancet Neurol. 2022; 21(2): 125–139. 4 –. Robbins R, et al. Front Sleep. 2022; 1: 935228. 5 – Di Marco T, et al. CNS Drugs. 2023; 37(7): 639–653. 6 – Kunz D, et al. CNS Drugs. 2022; 37(1): 93–106.

 

UK-DA-XXXXX | Date of preparation: February 2025

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