The direct impact of chronic insomnia on patients

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The direct impact of chronic insomnia on patients

Sleep is an essential pillar for good physical and mental wellbeing. During sleep, the body replenishes and repairs itself through cell and tissue growth. Without adequate, good-quality sleep, data show an overlap with poor general and mental health.20

The direct impacts of chronic insomnia on patients include:

  • Fatigue26

Poor or insufficient sleep has been found to increase negative emotional responses to stressors and to decrease positive emotions

Poor sleep reduces our ability to cope with low-stress conditions

Sleep helps maintain cognitive skills, such as attention, learning, and memory. Successive nights of restricted sleep results in gradually accumulating decline in cognitive function

Children are also vulnerable to sleep deficiency, which can lead to behavioural problems such as hyperactivity‑impulsivity, oppositional-aggressive behaviour, attention problems, social problems, withdrawn behaviour, negative mood and anxiety

Insomnia heightens the risk of falls among the elderly.31 Approximately one in every five falls in the elderly results in a severe injury, such as fractured bones or head trauma. 95% of hip fractures stem from falling incidents32

Insomnia elevates the risk of accidents at home, work and on the road

 

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The wider burden of chronic insomnia

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QUVIVIQ™ is indicated for the treatment of adult patients with insomnia characterised by symptoms present for at least 3 months and considerable impact on daytime functioning.34

This information is intended for UK healthcare professionals.

▼This medicine is subject to additional monitoring.

Adverse events must be reported. Healthcare professionals are asked to report any suspected adverse reactions via www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in Google Play or Apple App Store. Adverse events should also be reported to ds.safety.uk@idorsia.com

References

  1. World Health Organization (WHO). International statistical classification of diseases and related health problems (ICD) 11th revision. Available at: icd.who.int. Accessed August 2025
  2. Hafner M, Romanelli R J et al. The societal and economic burden of insomnia in adults: an international study. RAND Corporation, 2023
  3. Morin C M, Jarrin D C et al. Incidence, persistence, and remission rates of insomnia over 5 years. JAMA Netw Open 2020;3(11):e2018782
  4. Johnson E O, Roth T et al. Epidemiology of DSM-IV insomnia in adolescence: lifetime prevalence, chronicity, and an emergent gender difference. Pediatrics 2006;117(2):e247-256
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  11. Nowakowski S, Meers J, Heimbach E. Sleep and women’s health. Sleep Med Res 2013;4(1):1‑22
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  13. Park S Y, Oh M K et al. The effects of alcohol on quality of sleep. Korean J Fam Med 2015;36(6):294‑299
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  15. Morin C M, Drake C L et al. Insomnia disorder. Nat Rev Dis Primers 2015;1:15026
  16. Li J, Vitiello M V, Gooneratne N S. Sleep in normal aging. Sleep Med Clin 2018;13(1):1‑11
  17. Ferri P, Guadi M et al. The impact of shift work on the psychological and physical health of nurses in a general hospital: a comparison between rotating night shifts and day shifts. Risk Manag Healthc Policy 2016;9:203‑211
  18. Oh C M, Kim H Y et al. The effect of anxiety and depression on sleep quality of individuals with high risk for insomnia: a population‑based study. Front Neurol 2019;10:849
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  20. Lim D C, Najafi A et al. The need to promote sleep health in public health agendas across the globe. Lancet Public Health 2023;8(10):e820‑e826
  21. Singh N, Wanjari A, Sinha A. Effects of nicotine on the central nervous system and sleep quality in relation to other stimulants: a narrative review. Cureus 2023;15(11):e49162
  22. Drake C, Roehrs T et al. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. J Clin Sleep Med 2013;9(11):1195‑1200
  23. National Institute for Health and Care Excellence (NICE). Clinical knowledge summary. Insomnia. Scenario: managing short-term insomnia (less than 3 months duration), May 2025. Available at: cks.nice.org.uk. Accessed August 2025
  24. Kang J, Chen S. Effects of an irregular bedtime schedule on sleep quality, daytime sleepiness, and fatigue among university students in Taiwan. BMC Public Health 2009;9:248
  25. Blume C, Garbazza C, Spitschan M. Effects of light on human circadian rhythms, sleep and mood. Somnologie (Berl) 2019;23(3):147‑156
  26. National Institute for Health and Care Excellence (NICE). Clinical knowledge summary. Insomnia, May 2025. Available at: cks.nice.org.uk. Accessed August 2025
  27. Babson K A, Trainor C D et al. A test of the effects of acute sleep deprivation on general and specific self‑reported anxiety and depressive symptoms: an experimental extension. J Behav Ther Exp Psychiatry 2010;41(3):297‑303
  28. Minkel J D, Banks S et al. Sleep deprivation and stressors: evidence for elevated negative affect in response to mild stressors when sleep deprived. Emotion 2012;12(5):1015‑1020
  29. Dinges D F, Pack F et al. Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4‑5 hours per night. Sleep 1997;20(4):267‑277
  30. Astill R G, Van der Heijden K B et al. Sleep, cognition, and behavioral problems in school‑age children: a century of research meta‑analyzed. Psychol Bull 2012;138(6):1109‑1138
  31. Chen T Y, Lee S, Buxton O M. A greater extent of insomnia symptoms and physician‑recommended sleep medication use predict fall risk in community‑dwelling older adults. Sleep 2017;40(11): doi:10.1093/sleep/zsx142
  32. Centers for Disease Control and Prevention (CDC). Facts about falls, May 2023. Available at: cdc.gov. Accessed August 2025
  33. Léger D, Bayon V et al. Insomnia and accidents: cross-sectional study (EQUINOX) on sleep-related home, work and car accidents in 5293 subjects with insomnia from 10 countries. J Sleep Res 2014;23(2):143‑152
  34. QUVIVIQ™ Idorsia Pharmaceuticals Ltd, Summary of Product Characteristics

© NICE 2023 Daridorexant for treating long-term insomnia. Available from www.nice.org.uk/guidance/ta922. All rights reserved. Subject to Notice of rights.

NICE guidance is prepared for the National Health Service in England. All NICE guidance is subject to regular review and may be updated or withdrawn. NICE accepts no responsibility for the use of its content in this product/ publication.

UK-DA-00658 | Date of preparation: September 2025

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