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Mechanism of action of QUVIVIQ™▼ (daridorexant)

Exploring the mechanism of action of QUVIVIQ™

This video introduces the mechanism of action of QUVIVIQ™ (daridorexant) for chronic insomnia, highlighting its role in reducing overactive wake signalling by blocking orexin, allowing restorative sleep to occur without altering the proportion of sleep stages.1,2,4-8

Promotional material from Idorsia Pharmaceuticals UK Ltd.

References

1 – QUVIVIQ™ Idorsia Pharmaceuticals Ltd, summary of product characteristics.

2 – Roch C, et al. Psychopharmacology. 2021; 238(10): 2693–2708.

3 – NICE Clinical Knowledge Summary (CKS) Insomnia: Scenario: Managing long-term insomnia (more than 3 months duration). Available at: https://cks.nice.org.uk/topics/insomnia/management/managing-insomnia/. Updated May 2025. Accessed June 2025. 

4 – Mignot E, et al. Lancet Neurol. 2022; 21(2): 125–139.

5 – Robbins R, et al. Front Sleep. 2022; 1: 935228.

6 – Di Marco T, et al. CNS Drugs. 2023; 37(7): 639–653.

7 – Kunz D, et al. CNS Drugs. 2022; 37(1): 93–106.

8 – Chaput JP, et al. Nat Sci Sleep. 2018; 10: 421–430. 

This information is intended for UK healthcare professionals.

Adverse events must be reported. Healthcare professionals are asked to report any suspected adverse reactions via http://www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in Google play or Apple App store. Adverse events should also be reported to ds.safety.uk@idorsia.com.

UK-DA-00789
| Date of preparation: July 2025
Copyright © 2026 Idorsia Pharmaceuticals Ltd

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Discover how QUVIVIQ™ ▼ (daridorexant) is different to other hypnotics1,2:

Works differently1,2

Is taken differently1,3

Is experienced differently1,4

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References

1 – QUVIVIQ™ Idorsia Pharmaceuticals LTD, summary of product characteristics. Last updated: September 2024. 2 – Roch C, et al. Psychopharmacology. 2021; 238(10): 2693–2708. 3 – Mignot E, et al. Lancet Neurol. 2022; 21(2): 125–139. 4 –. Robbins R, et al. Front Sleep. 2022; 1: 935228. 5 – Di Marco T, et al. CNS Drugs. 2023; 37(7): 639–653. 6 – Kunz D, et al. CNS Drugs. 2022; 37(1): 93–106.

 

UK-DA-XXXXX | Date of preparation: February 2025

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